If I remember correctly, I think Conrad is responsible for plagues and stuff. But aside from that, and Griffith trying to fulfil his dream, do the God Hand do anything outside of accepting sacrifices and maybe doing stuff for the idea of evil? I remember when the count summoned them they were all just sorta standing together in astral world, and when the astral world merge happened ubik was just chilling in a dinner table with some people in a Hieronymus Bosch painting. But do they do stuff? Or do they just kinda fuck around in the astral world