Path of Exile is cool. It's fun to come back to the game once every few months, since the developers have usually added a ton of new stuff in that time. Like, since the last time I played, there seem to be entirely new leagues, rogue exiles, and some other pretty darn neat-sounding things.
I'm not sure if this is still the case, but in the past, the number one consideration for later levels has been to take lots of life nodes on the skill tree. It's very easy to become a glass cannon, and this is not one of those games that is still fun to play when you keep dying constantly.
There are some desync issues with the latest patches. This can lead to your characters death (plus the 15% exp penalty that comes along) they need to fix this issue. It has happened to me once, but since i am basically at the beginning of the game i don't really mind it.
Desync has been a problem for me for a long time, sadly, probably since the open beta. It might be partly my internet connection at fault, but the servers can sometimes be pretty poor.
It doesn't happen TOO often to me, so it's not a deal breaker, but it sucks to have your character demoted from Hardcore to Normal league through no fault of your own.