In Chapter 243 it seems that Casca may be sane again. Skull Knight implies that Casca may not share Gut's hopes of revenge, since it is Griffith. But c'mon Griffith sacrificed the entire Band of the Hawk and raped Casca pretty brutally and is the reason that Casca is a vegetable now, and that Casca's baby is a pre-mature demon.. thing. I think that Casca is going to want revenge on the God Hand, maybe not as much as Guts, and for some reason it's hard to see Casca wanting revenge like that, but look at the facts. I'd be pretty damn pissed off.